Preparation and Performance of Chitosan-gallic acid/Methacrylic Anhydride Composite Antibacterial Hydrogel

Abstract

Firstly, chitosan-gallic acid derivative (GA-CS) was prepared by reacting chitosan (CS) with gallic acid (GA), which was combined with chitosan (CM) modified by methacrylic anhydride (MA) acylation as an antibacterial modifier, and the composite hydrogel was prepared by light curing. The mechanical properties, swelling rate, surface contact angle, water retention and micromorphology of the hydrogel were tested to explore the effect of GA-CS on the antibacterial effect of the composite hydrogel. The results showed that the compressive strength of the composite hydrogel was 225kPa, and with the addition of the antimicrobial monomer GA-CS, the antibacterial effect and water retention rate of the composite hydrogel increased. However, the surface contact angle with water increased compared with that without GA-CS, and the swelling rate decreased. When the mass ratio of GA-CS to CM was 2:98, the diameter of the inhibition zone increased from 9.85mm to 13.96mm of the pure chitosan sample, the surface contact angle with water was 17.6°, the swelling rate of the sample was 79.32% in 24 hours, and the water content of more than 50% could be maintained for about 7 hours.