Abstract
Magnetite (Fe 3O 4) nanoparticles were prepared by coprecipitation of Fe 3+ and Fe 2+ with an aqueous NaOH solution. The Fe 3O 4–chitosan magnetic composite nanoparticles with a core–shell structure with a diameter of 30–50 nm were synthesized by two steps via a suspension cross-linking method. The inductive heating property of Fe 3O 4–chitosan composite nanoparticles in an alternating current (AC) magnetic field was investigated. The potential of Fe 3O 4–chitosan composite nanoparticles was evaluated for localized hyperthermia treatment of cancers. The saturation magnetization, M s, and coercivity, H c, were 65.53 emu g −1 and 0 Oe for Fe 3O 4 nanoparticles and 24.67 emu g −1 and 21.69 Oe for Fe 3O 4–chitosan composite nanoparticles, respectively. After exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspensions containing Fe 3O 4 nanoparticles or Fe 3O 4–chitosan composite nanoparticles were 97.5 °C and 53.7 °C, respectively. The Fe 3O 4–chitosan composite nanoparticles would be good thermoseeds for localized hyperthermia cancer therapy.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call