Preparation and Hemostatic Properties of Mesoporous Silica-based Xerogels

Abstract

A biodegradable silica-based xerogel with nano-scale mesopores was synthesized by using improved sol-gel process,and its hemostatic properties were investigated.The phase state,chemical structure,surface morphology,specific surface areas and mesoporous structure of the synthesized silica- based xerogels were measured systemically by means of X-ray diffraction(XRD),infrared spectrum (FTIR),transmission electron microscope(TEM),and N_2 adsoption-desoption(BET)techniques,re- spectively.The effects of the silica-based xerogel on intrinsic and extrinsic blood clotting systems were examined through the activated partial thromboplastin time(APTT)and prothrombin time(PT)tests in vitro,respectively.The hemostatic performance of the prepared silica-based xerogel was evaluated at the rabbit's ear side veins compared with a traditional hemostatic dressing(Yunnan Baiyao).The results reveal that the non-crystalline silica-based xerogel with 901.17m~2/g specific surface areas and 3.255nm in apertures is obtained after calcining at 600℃.The silica-based xerogel facilitates both of the intrinsic and extrinsic clotting activities significantly.The silica-based xerogel has good hemostatic effect on the rabbit's ear side veins which is better than that of the Yunnan Baiyao.