Preparation and evaluation of press coated floating pulsatile drug delivery system of telmisartan

Abstract

The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Telmisartan used for is a medication used for high blood pressure, heart failure, and diabetic kidney disease. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Telmisartan in the inner core were formulated by direct compression method with an outer coating of different amount of Chitosan. The release profile of press coated tablet exhibited a lag time. The optimized batch F9 gave good drug release of 99.58 %