Preparation and Evaluation of Niosomal Gel Loaded With Combination of Isotretinion and Clindamycin

Abstract

The objective of the present study was to formulate topical niosomal gel loaded with combination of Isotretinion and Clindamycin for the beneficial of acne patients, to provide sustained release effects, to prevent their side effects. First generation topicals retinoids (Isotretinion) and antibacterials (Clindamycin) target comedones, Propionibacterium acnes or inflammation. The combination of Isotretinion and Clindamycin is reported to treat almost all type of acne and have potential to increase both efficacies, patient adherence as compared to single agent treatment. Purpose of this study was to develop a stable formulation that allows progressive follicle penetration and increased efficacy. Preformulation studies such as melting point, FTIR spectroscopy, UV spectroscopy, solubility, partition coefficient (log P) were performed for both drugs. The niosomal combination of both drugs was incorporated into the carbopol gel. The pH and viscosity of gel was performed.