PREPARATION AND EVALUATION OF CO-CRYSTALS OF CARBAMAZEPINE WITH GLUCOMANNAN

Sharwaree Hardikar,Ashok Bhosale,Bhagyashree Kamathe,Swati Vanave

doi:10.22159/ijpps.2017v9i10.20656

Sharwaree Hardikar, Ashok Bhosale + Show 2 more

Open Access

https://doi.org/10.22159/ijpps.2017v9i10.20656

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Abstract

Objective: The objective of the present work was to inhibit transformation of carbamazepine anhydrous to its dihydrate form in aqueous medium by adopting the co-crystal approach.Methods: Co-crystallization of carbamazepine and glucomannan as co-former was carried out by solution mediated phase transformation. The solution of carbamazepine and glucomannan in ethanol (95%) was agitated for 2 h and the co-crystals obtained were recovered after 24 h.Results: Co-crystal formation due to hydrogen bonding between carbamazepine and glucomannan as a co-former was confirmed by FTIR study. Inhibition of transformation of co-crystal of carbamazepine to carbamazepine dihydrate in aqueous medium was confirmed by SEM.Conclusion: Inhibition of transformation of carbamazepine co-crystal to its dihydrate form resulted in its improved dissolution. Dissolution efficiency of carbamazepine in its co-crystal was increased up to 79.26% within 30 min.

Highlights

Carbamazepine transforms to its dihydrate form when it comes in contact with the aqueous medium
It is reported in the literature that co-crystal formation of carbamazepine is a suitable approach to increase its rate of dissolution
Transformation of carbamazepine to dihydrate form is prevented when carbamazepine is in its co-crystal form

Summary

Introduction

Carbamazepine transforms to its dihydrate form when it comes in contact with the aqueous medium. Since dihydrate form of carbamazepine is three times lesser soluble (0.12 mg/ml) as compared to its anhydrous (0.38 mg/ml) form; such transformation is a critical parameter that affects its dissolution and bioavailability [1]. It is reported in the literature that co-crystal formation of carbamazepine is a suitable approach to increase its rate of dissolution. Transformation of carbamazepine to dihydrate form is prevented when carbamazepine is in its co-crystal form.

Results

Conclusion