Preparation and characterization of Terminalia bellerica loaded PCL nanofibrous mats for biomedical applications

Abstract

Wounds are big challenges to the wound care professionals. Topical wound care products and wound dressings are evolved every day. Advanced dressings are produced by incorporating antimicrobial agents, growth factors and herbal extracts to enhance the wound healing process. Nanofibres are the recent focus as drug delivery vehicle for the delivery of drugs to the target site. The aim of the study is to prepare Terminalia bellerica loaded PCL nanofibrous mats by electrospinning and to characterize the nanofibres for biomedical applications. Terminalia bellerica is one of the ingredients of Triphala which play important role as rejuvenating agent. The increasing concentration of Terminalia loaded PCL nanofibrous mats shows increased fiber diameter, wettability and Water uptake property. The wettability of the PCL was decreased from 113.3 ± 3.62 to 59.98 ± 4.99, 44.96 ± 7.04 and 34.34 ± 3.45 respectively for the Terminalia loaded PCL nanofibres. The 5% herbal loaded PCL nanofibrous mats shows antimicrobial activity against gram negative bacteria. Further, Terminalia loaded PCL mats were found to be nontoxic and is responsible for the cell adhesion and proliferation and is useful as the potential candidate for wound dressing applications.