Abstract
This study focused on the fabrication, characterization, and release properties of electrospun tea polyphenol (TPP) loaded porous core-shell structured fibers. The morphology, structure and properties of the electrospun TPP loaded porous core-shell fibers were investigated by a combination of Fourier transformation infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle (CA) measurements, transmission electron microscopy (TEM), etc. In addition, the cumulative drug release rate of TPP loaded porous core-shell fibers was determined by ultraviolet (UV) spectrophotometer, and the release mechanism was investigated using Fickian diffusion equation, which would provide the theoretical basis for future study. The results showed TPP loaded porous core-shell structured fibers were successfully prepared by coaxial electrospinning, and the porous structure of the core-shell fibers could further enlarge the specific surface area, enhance the hydrophobic properties, and improve the drug release properties.
Highlights
IntroductionDrug loaded nanofiber membranes prepared by single electrospinning usually show an initial burst release because of the high concentration of the drug distributed on the nanofiber surface
Drug loaded nanofiber membranes prepared by single electrospinning usually show an initial burst release because of the high concentration of the drug distributed on the nanofiber surface.The core-shell nanofibers, in which the drug is restricted to the core layer, is expected to limit the release of the drug during the initial stage [1]
The results showed the porous structure of the electrospun core-shell fibers further enlarged the specific surface area, enhanced the hydrophobic property, and improved the release property of tea polyphenol (TPP)
Summary
Drug loaded nanofiber membranes prepared by single electrospinning usually show an initial burst release because of the high concentration of the drug distributed on the nanofiber surface. When proper polymer systems are employed, and parameters are adjusted, ideal core-shell structured nanofibers can be produced, and the release behavior can be effectively controlled. Recent research showed that the single electrospinning process can be used to fabricate nanofibers with porous surface by adjusting electrospinning parameters, and the porous structure could promote release of drug [2,14,15]. TPP loaded porous core-shell fibers were prepared successfully by controlling coaxial electrospinning parameters. The cumulative drug release rate of TPP from the core-shell fibers was measured in Phosphate buffer saline (PBS) for a period of 141 h using ultraviolet (UV) spectrophotometer. The results showed the porous structure of the electrospun core-shell fibers further enlarged the specific surface area, enhanced the hydrophobic property, and improved the release property of TPP
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