Abstract
Nanoparticles were prepared by emulsion solvent evaporation method, using methylene chloride (DCM) as the organic solvent and poly vinyl alcohol (PVA) as the surfactant. Different formulation conditions such as surfactant concentration, drug amount, homogenization time, aqueous phase volume were investigated for drug entrapment efficiency, drug loading and particle size. It was found that PVA concentration less than 1% was unable to form a stable emulsion, increasing drug amount more than 30 mg didn't lead to any significant difference in drug entrapment efficiency or particle size, homogenization for 2 minutes led to particles having larger size and higher entrapment efficiency than those obtained after 3 minutes homogenization, increasing the aqueous phase volume from 40 ml to 80 ml led to a significant increase in entrapment efficiency and a significant decrease in particle size.
Highlights
Nanoparticles were prepared by emulsion solvent evaporation method, using methylene chloride (DCM) as the organic solvent and poly vinyl alcohol (PVA) as the surfactant
Nanotechnology is the science involved in the design, synthesis, characterization and application of materials and devices whose smallest functional organization is on the nanometer scale at least on one dimension (Sahoo and Labhasetwar 2003)
Emulsion solvent evaporation is the most common method used for the encapsulation of hydrophobic drugs where both the drug and the polymer are dissolved in an organic phase which is emulsified with the aqueous phase
Summary
Nanoparticles were prepared by emulsion solvent evaporation method, using methylene chloride (DCM) as the organic solvent and poly vinyl alcohol (PVA) as the surfactant Different formulation conditions such as surfactant concentration, drug amount, homogenization time, aqueous phase volume were investigated for drug entrapment efficiency, drug loading and particle size. Polymeric NPs are considered a versatile medium for the delivery and monitoring of highly toxic compounds in vivo due to their enhanced biological stability and extended in vivo circulation They account for more than 80% of the available therapeutics in clinical use (Ravi Kumar 2000) due to their small particle size which facilitates their penetration into smaller capillaries and their subsequent uptake by the cells, which allows efficient drug accumulation at the target sites. The thermoplastic aliphatic poly(esters) such as polylactic acid(PLA), polyglycolic acid (PGA) and, especially PLGA, have generated tremendous interest due to their excellent biocompatibility, biodegradability and toxicologically safe by-products (Acharya and Sahoo 2011)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
