Preparation and Characterization of Glipizide Loaded Eudragit Microparticles

Abstract

Background: Glipizide is an oral anti-diabetic drug used for the treatment of type II diabetes. Eudragit polymers are widely used for the sustained and targeted release of drugs. Encapsulated glipizide microparticles were developed using Oil-in-Water emulsion using Eudragit RS 100 -RL 100 in combination for sustained release of glipizide and its characterization for drug release and kinetics study. Objective: To develop glipizide loaded microparticles using combination of Eudragit RS 100 -RL 100 and to characterize for drug polymer interaction, surface morphology and drug release. Method: A 32 full factorial design was utilized for the preparation of microparticles and to understand the effect of input variable on output variables. The microparticles were characterized by Fourier Transform Infrared Spectroscopy for compatibility of drug and polymer, X-Ray diffractometer for crystallinity, Field emission scanning electron microscope for morphology study and in vitro drug release behaviour. Results: Percentage encapsulation efficiency and drug loading were obtained in the range of 45.5- 98.92% and 9.5-24.72% respectively. FTIR reveals the absence of chemical interaction between drug and polymer. XRD showed a reduction in crystallinity of drug. FE-SEM displayed spherical, nonaggregated porous microparticles. In vitro drug release studies showed sustained release of drug over a period of 12 h. Conclusion: The microparticles developed by this method were spherical and porous. The absence of drug-polymer interactions was confirmed by FTIR. Distribution of the drug within the polymers was confirmed by XRD. In vitro drug release studies showed sustained release of drug from encapsulated microparticles.