Abstract
Chitosan (CS) microparticles with and without cross-linking were prepared by a water-in-oil emulsion solvent diffusion method without any surfactants. Aqueous CS solution and ethyl ace- tate were used as water and oil phases, respectively. Genipin was used as a cross-linker. Influ- ences of genipin ratios and cross-linking times on CS microparticle characteristics were investigated. Non-cross-linked and cross-linked CS microparticles were spherical in shape and rough in surface. Microparticle matrices showed porous structures. Surface roughness, mean par- ticle sizes and bulk density of CS microparticles increased and their dissolutions in acetic acid solution decreased when genipin ratio and cross- linking time increased.
Highlights
Chitosan is a copolymer of 2-glucosamine and Nacetyl-2-glucosamine prepared by alkaline deacetylation of chitin that has received great attention for its possible uses in medical, pharmaceutical and metal ion treatment applications because of its biodegradability, biocompatibility and high concentration of amine functional groups [1,2,3,4]
Each average percentage of dissolution value was calculated from a mean of three measurements. where initial and remaining CS microparticles are the weights of chitosan microparticles before and after dissolution test, respectively
The surface roughness of microparticles increased with genipin ratio and crosslinking time but the particle shape did not change
Summary
Chitosan is a copolymer of 2-glucosamine and Nacetyl-2-glucosamine prepared by alkaline deacetylation of chitin that has received great attention for its possible uses in medical, pharmaceutical and metal ion treatment applications because of its biodegradability, biocompatibility and high concentration of amine functional groups [1,2,3,4]. Chitosan microparticles have usually been fabricated by precipitation, spray drying and water-in-oil (W / O) emulsification-cross-linking methods [5]. The current study describes an alternative method for preparation of cross-linked and non-cross-linked CS microparticles by the W / O emulsion solvent diffusion method. The CS device matrices were successfully cross-linked with genipin [8,9,10]. A novel approach to the preparation of genipin-cross-linked chitosan microparticles by the simple W / O emulsion solvent diffusion method is reported. Cross-linked chitosan microparticles were solidified and formed after diffusion out of water from emulsion droplets of chiosan solution to external continuous phase, ethyl acetate. The influences of cross-linker ratio and cross-linking time on CS microparticle characteristics including morphology, particle size, dissolution and bulk density were investigated and discussed
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