Preparation and Characterization of Fe-Gallic acid MOF for determination of antiviral Molnupiravir as inhibitor for RNA Corona virus replication

Abstract

Fe-Gallic acid metal organic framework (MOF) was synthetized and characterized by acquired qualitative and quantitative micro analytical tools such as: FE-SEM/EDX, XPS analysis, XRD analysis, FT-IR, and Fluorescence spectroscopy. Fe-Gallic acid MOF is used as a sensor for the determination of antiviral Molnupiravir (MOL) in pharmaceutical formulations, urine and serum samples. The existence of adequate functional groups in (MOL) solution in DMSO induces the interaction with the Fe- Gallic acid MOF complex that absorb energy at the characteristic wavelength of the organic ligand (λex = 290 nm) and emits radiation at 357 nm over a working range of 1 × 10−5 − 1 × 10−9 mol/L. The Fe-Gallic acid MOF sensor is a sensitive and cost-effective method for the detection of Molnupiravir. It has a detection limit of 2.24 × 10−9 mol/L, which is lower than other methods for the detection of Molnupiravir. The Fe-Gallic acid MOF sensor is also easy to use and does not require any special equipment. It is a promising new method for the detection of Molnupiravir, and it could be used in a variety of settings, including clinical laboratories and point-of-care settings.