Preparation and Characterization of Chitosan coated alginate and carrageenan beads Loaded with Venlafaxine HCl: A Comprehensive Study

Abstract

This study focuses on the development of microsphere systems for the sustained release of Venlafaxine Hydrochloride (HCl) using the ionotropic gelation method with sodium alginate, chitosan, carrageenan and calcium chloride as key components. The microspheres were characterized for their size, shape, and surface morphology using scanning electron microscopy (SEM). X-ray powder diffraction analysis (X-RD) was employed to determine the physical state of the drug within the formulations, while Fourier-transform infrared spectroscopy (FTIR) was used to investigate the drug-polymer interactions. Additionally, entrapment efficiency, in vitro release, and release kinetics were evaluated.The results of FTIR analysis indicated no significant interactions between the drug and polymers, ensuring the stability of the formulated microspheres. X-RD analysis confirmed the presence of the drug in an amorphous state within the beads, facilitating its sustained release. Furthermore, the absence of significant drug-polymer interactions, as indicated by FTIR analysis, supports the stability and integrity of the formulated beads. In conclusion, the developed microsphere systems demonstrate promising potential for the sustained release of Venlafaxine HCl. Their high entrapment efficiency, controlled release rate, and stability make them viable option for improving the therapeutic efficacy and patient compliance associated with Venlafaxine HCl administration. Further studies are warranted to evaluate their pharmacokinetic and pharmacodynamic profiles, as well as their long-term stability, to ensure their suitability for clinical applications.