Preparation and characterization of BSA and chitosan nanopartices for sustainable delivery system for quercetin

L Raj,E Jayalakshmy,B Revathi,R Jonisha

doi:10.7324/japs.2015.50701

Abstract

Antibacterial and antiviral activities of chitosan nanoparticles from the American cockroach, Periplaneta americanaMahmoud T. Mahboub, Mostafa I. Hassan, Ahmed S. Bream, Aly F. Mohamed, Mohammad R. K. Abdel-Samad

Highlights

Drug delivery is a promising approach for the biotechnologist and pharmacologist to develop a delivery system that can aid the drug to its target and maintaining its availability for their therapeutic action
Bovine Serum Albumin (BSA) and chitosan nanoparticles were prepared by using desolvation and ionic gelation method and this was confirmed by Scanning Electron Microscope (SEM) analysis with the minimum particle size
It was clear that successful encapsulation of Quercetin in chitosan nanoparticle will provide the bioavailability of Quercetin in the system

Summary

Introduction

Drug delivery is a promising approach for the biotechnologist and pharmacologist to develop a delivery system that can aid the drug to its target and maintaining its availability for their therapeutic action. Efficacy of most of the drugs were limited for several reasons such as poor absorption, poor solubility, nonspecific delivery, short circulating half life, high toxicity, high dosage etc (Orive et al, 2003; Praveen et al, 2012) It is always a dream for the scientist to develop a drug with the higher degree of specificity, solubility, improved efficacy with lesser side effects. Researchers have recognized the nanotechnology as a best solution to overcome the above said problem in developing an effective drug Numerous nanotechnology platforms such as fullerenes, nanotubes, quantum dots, nanopores, dendrimers, liposomes, magnetic nanoprobes and radio controlled nanoparticles are being indentified so far (Faraji and Wipf, 2009). Nanoparticles that are compatible to the biological system have numerous applications

Methods

Results

Conclusion