Abstract
In this paper, a polylactic acid (PLA)/polybutylene carbonate (PBC)/chitosan (CS) composite membrane with different mass fractions of ciprofloxacin hydrochloride (CipHCl) drug was prepared through the electrostatic spinning technology. The morphology and chemical structure of the resultant CipHCl-PLA/PBC/CS fiber membranes were characterized with scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). A drug-release test, bacteriostatic test and cytotoxicity test were performed to determine the drug-release properties, bacteriostatic properties and cytotoxicity, respectively. Results show that the CipHCl-PLA/PBC/CS composite fiber membranes have good biocompatibility. When the CipHCl content is 20 w/%, the average fiber diameter is 374 nm. After 192 h, the drug-release rate of the CipHCl-PLA/PBC/CS composite fiber membrane containing 20 w/% of CipHCl reaches 88.2 %. The antibacterial activity of the CipHCl-PLA/PBC/CS composite fiber membrane is much higher than that of the PLA/PBC composite fiber membrane. Besides, the antibacterial activity of the CipHCl-PLA/PBC/CS composite fiber membrane against E. coli is slightly higher than that against S. aureus.
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