Abstract
The aim of this paper was to synthesize ortho hydroxytoluene chitosan for hemostatic use. A series of modified chitosan were prepared by reductive amination through adjusting the dosages of salicylaldehyde and sodium borohydride. FTIR, elemental analysis and XRD tests were performed to analyze the composition, degree of substitution (DS) and crystallisability of chitosan derivatives. Rheological and blood coagulation experiments were carried out to measure its gel-forming and hemostasis property in vitro. The results showed ortho hydroxytoluene groups could be grafted on chitosan, DS value can be adjusted by the dosage of reactive agents, and the crystallinity of chitosan changed obviously after modification. The rheological results indicated high substituted (≥26.79 mol-%) ortho hydroxytoluene chitosan could gel blood and showed better blood coagulation property. High substituted ortho hydroxytoluene chitosan could improve hemostatic property significantly.
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