Preparation and Biological Activity of Strontium Modified Titanium Oxide Surface

Abstract

Titanium (Ti) is a bone tissue replacement material with excellent mechanical properties. However, Ti has poor biological activity and lacks osseointegrative properties and may trigger inflammation and cause implantation failure. To address these issues, Ti surface modification has become a widely used method. In this study, using microarc oxidation (MAO) technology, a strontium-doped MAO coating was prepared on Ti surfaces in an electrolyte solution comprising calcium acetate, calcium glycerophosphate and strontium acetate. Scanning electron microscopy (SEM) and energy spectrum analysis (EDS) were used to analyze the tissue structure and elemental composition of the coating. The surface phase composition of the coating was analyzed by X-ray diffraction (XRD). We observed the proliferation of cells on the coating surface through in vitro cell experiments. The results showed the surface of the strontium-doped MAO coating is porous, and strontium is evenly distributed on the surface. The coating can promote the adhesion, proliferation and differentiation of osteoblasts and has good biological activity and thus, could potentially be applied to the surface of implants in clinical application.