Abstract
In recent years, the rising number of bone diseases which affect millions of people worldwide has led to an increased demand for materials with restoring and augmentation properties that can be used in therapies for bone pathologies. In this work, PMMA- MBG composite scaffolds containing ceria (0, 1, 3 mol%) were obtained by the phase separation method. The obtained composite scaffolds were characterized by X-ray diffraction, infrared spectroscopy, and scanning electron microscopy. UV–Vis measurement and EDX analysis confirmed the presence of cerium ions in the composite scaffolds. Evaluation of the in-vitro biocompatibility using MTT assay showed that composite scaffold containing 1 mol% of ceria presented higher viability than control cells (100%) for concentrations ranging between 5 and 50% after 96 h of incubation.
Highlights
Developments in tissue engineering have raised significantly the potential for treating bone defects caused by trauma, tissue resection, congenital anomalies, cancer, and osteoporosis [1]
PMMA-Ce doped MBG composite scaffolds with promising potential for application in tissue engineering were prepared by phase separation method by combining MBGs with addition of 0, 1, and 3 mol% ceria and PMMA
An in vitro biocompatibility evaluation determined using MTT assay indicated that all tested samples showed no cell cytotoxic activity on L929 cells in the concentration range of 5–75% after 96 h of incubation
Summary
Developments in tissue engineering have raised significantly the potential for treating bone defects caused by trauma, tissue resection, congenital anomalies, cancer, and osteoporosis [1]. Scaffolds manufactured from natural or synthetic materials that provide structural support allowing cell proliferation upon transplantation, have become one of the important elements for regenerative medicine [2]. The synthetic scaffolds can overcome limitations in current treatments associated with autologous bone grafting such as immunological rejection, the possibility of transmitting infectious diseases and low tissue availability [3,4]. To obtain scaffolds with the best properties, different types of materials have been used, such as natural or synthetic polymers, bioglasses, ceramics, metals, composites, and hydrogels. Mechanical properties, biocompatibility, bioactivity, surface properties and biodegradability are essential in regenerative medicine applications and need to be considered when designing a scaffold [5]
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