Abstract
Porous polymer microspheres have been widely used in separation and purification of drugs, which are a series of important biochemical engineering products. Formation of porous microspheres is a complex process. Microspheres with pore size below 100 nm is obtained by phase separation of polymers and porogens, while microspheres with pore size above 100 nm can be obtained by phase separation of polymers and water. The porous microspheres with different structures should be delicately designed to meet the application needs. Suspension and seeded polymerizations methods which can be used to fabricate macro-, meso- and nanoporous microspheres are reviewed. Besides, reverse micelles swelling and double emulsion methods are introduced in detail to prepare gigaporous microspheres based on our group 's research. HB-VLPs are used to prove the advantages of gigaporous microspheres in biomacromolecules purification by comparison with mesoporous microspheres.
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