Abstract
In recent years, micro/nano-scaled separation technique has attracted increasing attention due to its inherent advantages. The porous layer open tubular (PLOT) capillary column is an important micro-column form. Compared to wide-bore PLOT capillary columns (inner diameter > 25 μm), the PLOT capillary columns with narrow inner diameters yield higher separation efficiencies and lower reagent consumption. In this paper, the preparation methods for porous layer open tubular capillary columns with narrow inner diameters, less than or equal to 25 μm, are reviewed. Detection techniques combined with mass spectrometry and their applications in liquid chromatography are also discussed.
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