Abstract
IntroductionSulforaphane (SFN) has anti-inflammatory properties, and is found in broccoli sprouts. Studies suggest that it protects against disease due to its anti-inflammatory activity. The impact of SFN on healthy people undergoing a surgical procedure has not been investigated. ObjectiveTo explore the effect of SFN in living kidney donors on the postoperative inflammatory response and recovery. MethodsWe performed a double-blind randomised controlled trial where donors followed a SFN-enriched (8 mg) preoperative diet. ResultsA total of 42 donors were included, there were no significant differences at baseline. Postoperative inflammatory response was consistent among both arms and subjective recovery showed no significant difference. Findings regarding postoperative kidney function suggest no consistently significant impact. DiscussionA well-defined SFN-enriched diet did not have anti-inflammatory or a clinically relevant effect on the outcome. Due to the complexity of dietary modification of the inflammatory response, additional research is needed.
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