Abstract
Adenylosuccinate synthetase, a dimeric enzyme of 96,000 M r, catalyzes the first committed step toward the de novo biosynthesis of AMP. Large, single crystals of adenylosuccinate synthetase from Escherichia coli grow from solutions of polyethylene glycol and ammonium sulfate. Crystals from ammonium sulfate belong to the orthorhombic space group P2 12 12 1 with unit cell parameters a = 79.0 A ̊ , b = 70.2 A ̊ and c = 152.6 A ̊ . Crystals from polyethylene glycol belong to the space group P2 1, having unit cell parameters of a = 71.16 A ̊ , b = 71.99 A ̊ , c = 82.95 A ̊ , and β = 71.52 ° . The asymmetric units of both crystal forms probably contain the entire dimeric enzyme.
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