Abstract
OBJECTIVE: Polycystic Ovarian Syndrome (PCOS) is the most common disease presenting hyperandrogenism, and accounts for 70∼80%. Study showed PCOS hyperandrogenism is often caused by 17α-hydroxylase/17,20-lyase hyperfunction. Therefore the key enzyme in androgen biosynthesis became potential therapeutic target for anti-hyperandrogenism therapy. The objective of this study is to verify the knockdown effect of constructed CYP17 lentivirus shRNA on cultured rat ovarian theca interstitial cells, and establish a method for in vivo study of inhibiting androgen biosynthesis by RNA interference in the future.
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