Abstract
<p dir="ltr"><span>The investigation on anti-inflammatory activity of the various extract of </span><span>Waltheria indica </span><span>L. </span><span>was reported to find out the pharmacological basis for its ethnomedical use. </span><span>The anti-inflammatory activity of the pet ether (PEW) and methanol (MEW) extracts of the leaves of </span><span>Waltheria indica </span><span>L. (</span><span>Malvaceae</span><span>)</span><span>were evaluated by using in vivo (Carrageenan &amp; histamine induced rat paw edema, cotton pellet granuloma test) models. It was observed that, all the extracts showed significant activity in the in-vivo model at the dose of 500 mg/kg b.w. orally, when compared with control and standard drugs. Of the two extracts tested, methanol extract MEW showed most significant activity well in comparison to the standard drug. Therefore, present study suggests, potential of leaves of </span><span>Waltheria indica </span><span>L. in both models of acute and chronic inflammation.</span></p><p dir="ltr"> </p>
Highlights
Inflammation is part of the complex biological response of body tissues
The overall results showed that the methanolic extract (MEW) from W. indica, aerial parts exhibited a significant anti-inflammatory activity against animal models in mice and rats induced by various factors
Since it is evident that carrageenan induced edema is commonly used as an experimental model for acute inflammation and is believed to be biphasic, of which first phaseis mediated by the release of histamine and 5-HT in the early stage followed by kinin release and prostaglandin in the latter phase(1)
Summary
India 2University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, C.G., India 3Ph. D. Research Scholar University Institute of Pharmacy Pt. Ravishankar Shukla. University Raipur (C.G.) 492 010, INDIA 4Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Mumbai, Maharashtra, India. The investigation on anti-inflammatory activity of the various extract of Waltheria indica L. was reported to find out the pharmacological basis for its ethnomedical use. The anti-inflammatory activity of the pet ether (PEW) and methanol (MEW) extracts of the leaves of Waltheria indica L. All the extracts showed significant activity in the in-vivo model at the dose of 500 mg/kg b.w. orally, when compared with control and standard drugs. Of the two extracts tested, methanol extract MEW showed most significant activity well in comparison to the standard drug.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
