Abstract
Objective:To evaluate the anti-inflammatory activity of exogenously administered polyamines on experimentally induced acute and chronic inflammation in wistar rats and to elucidate their possible mechanism of action.Materials and Methods:The in vivo anti-inflammatory activity of polyamines was studied using acute (carrageenin paw edema), sub-acute (cotton pellet granuloma) and chronic (Freund's adjuvant induced arthritis) models of inflammation. The biochemical parameters like liver lipid peroxides, SGOT and SGPT were also measured.Results:Polyamines exhibited significant anti-inflammatory activity in acute, sub-acute and chronic models of inflammation. Polyamines treatment inhibited the increase in lipid peroxides in liver and the serum concentration of marker enzymes (glutamate oxaloacetate transferase and glutamate pyruvate transferase) during inflammation.Conclusion:Polyamines possess anti-inflammatory activity in acute and chronic inflammation which can be attributed to their anti-oxidant and /or lysosomal stabilization properties.
Highlights
The polyamines putrescine, spermidine and spermine are aliphatic polycations derived from ornithine and play vital physiological roles.[1]
Polyamines treatment inhibited the increase in lipid peroxides in liver and the serum concentration of marker enzymes during inflammation
Polyamines possess anti-inflammatory activity in acute and chronic inflammation which can be attributed to their anti-oxidant and /or lysosomal stabilization properties
Summary
The polyamines putrescine, spermidine and spermine are aliphatic polycations derived from ornithine and play vital physiological roles.[1]. Polyamines have been postulated to have anti-inflammatory and anti-oxidant properties.[1] It has been suggested that they exert at least two different anti-inflammatory mechanisms, the first one is mediated by the synthesis of an anti-inflammatory protein (vasoregulin)[5] and the second one is their direct action on leucocytes.[6] Most of the reported studies have been conducted on several cell-lines in vitro and those in vivo have been of a preliminary nature. They have not been investigated in chronic models of inflammation. Several have been investigated to correlate them with the antiinflammatory activity of polyamines
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