Abstract
Objective: To estimate the antimicrobial activity of the leaf extract of Thunbergia coccinea in association with phytochemical analysis.
 Methods: The extraction of the leaves of Thunbergia coccinea was done by using a various solvent like petroleum ether, chloroform and methanol. The phytochemical constitutes are investigated by using standard methods. Antimicrobial activity of leave extract was carried out against gram positive bacteria (Staphylococcus aureus) and one gram negative bacteria (Escherichia coli). The anti-fungal activity of the plant extract was evaluated on Candida albicans. The testing was done by using disc diffusion method. The zone of inhibition was compared with standard Amikacin for anti-bacterial activity and fluconazole for anti-fungal activity.
 Results: The present investigation shows the phytochemical analysis which revealed the presence of alkaloid, flavonoid, cardiac glycoside, saponin glycoside, tannin and phenolics. The antimicrobial activity of plant extract is showed significant result against all three of the test organism.
 Conclusion: The present study concluded that the leaf extract of Thunbergia coccinea contain various phytochemicals and possess promising antimicrobial activity when compared with the standards.
Highlights
Medicinal plants have been used from the ancient time to prevent and treat various health problems
According to World Health Organization (WHO) more than 80% of the world's population relies on traditional medicine for their primary healthcare needs
The present study shows the phytochemical screening and antimicrobial activity of plant extract of different solvent
Summary
Medicinal plants have been used from the ancient time to prevent and treat various health problems. Plants are still an independent source of medication in the contemporary health care delivery system. Their role is twofold in the development of medicines and served as a natural blue print for the development of new drugs [1]. Plants used for traditional medicine contain a wide range of substances that can be used to treat chronic as well as communicable diseases. Medical plants contain large varieties of chemical substances, which possess important therapeutic properties that could be utilized in the treatment of human diseases. Plants are rich in a wide variety of secondary metabolites such as tannins, alkaloids, phenolic compound and flavonoids, which have been found in vitro to have antimicrobial properties [5, 6]
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