Abstract
Objective: To estimate the antimicrobial activity of methanolic extract of Adenium obesum (family Apocyanaceae) in association with phytochemical analysis.
 Methods: The methanolic extract of the flowers of Adenium obesum was prepared and investigated for phytochemical constituents using standard methods. Antimicrobial activity of methanolic extract Adenium obesum has been carried out against one gram-positive bacteria Staphylococcus aureus and one gram-negative bacteria Escherichia coli and the antifungal activity of the plant extract was evaluated on Candida albicans species. The testing was done by the disc diffusion method to visualize the zone of inhibition of methanolic extract was compared with that of standard drug i.e., Ciprofloxacin for antibacterial activity and Fluconazole for antifungal activity. The minimum inhibition concentration was determined by micro dilution method (cup-plate method).
 Results: The present investigation shows the phytochemical analysis confirmed the presence of alkaloids, saponin glycosides, flavonoids, phenols, proteins and amino acids, cardiac glycosides, steroids, tannin, and phenolic compounds. The anti-microbial activity of the methanolic extract of the plant showed significant results against all the three of the test organisms in compare to the standard drugs.
 Conclusion: The present study concluded that methanolic extract of the flowers of adenium obesum proved the existence of phytochemical constituents. The methanolic extract of the was found to possess promising antimicrobial activity when compared with the standards and it can be useful for the development of antibiotics.
Highlights
For a long period of time, there are many naturally occurring materials which are having biologically active substance and show biological activity for the health of human beings and they have great potential for producing new drugs
The pant exhibits anticancer, antiviral, antibacterial, trypanocidal, acarcidal, molluscicidal, antioxidant and piscicidal activities [13]. The target of this present study is to identify the phytochemical components of Adenium obesum and to determine the antimicrobial effects of the dried flower extract on E. coli, S. aureus and Candida albicans
The phytochemical analysis with the methanolic extracts of the dried flowers of plant Adenium obesum showed the presence of alkaloids, saponin, sterols, terpeniods, protein and amino acids, tannins, carbohydrates
Summary
For a long period of time, there are many naturally occurring materials which are having biologically active substance and show biological activity for the health of human beings and they have great potential for producing new drugs. The use of naturally occurring antimicrobial substance is gaining more importance and have higher significant value [1]. Medicinal plants have an important role for the health of individuals and communities. These plants have a great medicinal value that lies in various chemical substances which produce physiological action on the human body. According to WHO medicinal plants are used in order to the therapeutic purpose and can be used as processing the synthesis, semi-synthetic chemical drugs [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
