Abstract
Cholesterol is necessary for many cell functions but it can also be harmful if it is allowed to reach high blood concentrations, as the risk for premature atherosclerotic cardiovascular diseases increases. Many food supplements contain currently 10 mg of monacolin K in order to benefit of the approved claim to maintain normal blood LDL-cholesterol levels. However, the EFSA has considered that cases of adverse reactions have been reported for monacolins from red yeast rice at intake levels as low as 3 mg/day. That is the reason why the main aim of the present study was to show the effect of Policol<sup>®</sup> One new formula in patients with non-desirable lipidic profile levels. Policol<sup>®</sup> One new formula contains a wide range of plant extracts with not only a traditional use, but also a proven effect on plasma lipids. The consumption of one capsule of new Policol<sup>®</sup> One during dinner for only 4 weeks favorably affected plasma LDL-C (-39.52%) and TC (-40.52%) levels in healthy volunteers. No significant effect on TG and HDL-C was shown after 4 weeks. However, after 12 weeks TG biomarker exhibited a significant reduction (-19.91%) and HDL-C (+9.84%) also improved. No adverse effects were reported during the study. Lower lipid properties may be associated with a synergistic effect of the ingredients which allow us to formulate with a lower and safer dosage of monacolin K.
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