Preliminary clinical study of left ventricular systolic dyssynchrony in patients with coronary heart disease by real-time three-dimensional echocardiography

Abstract

Objective To figure out the preliminary clinical value of real-time three-dimensional echocardiography( RT-3DE) in evaluating the systolic dyssynchrony in patients with coronary artery heart disease(CAD). Methods Eighty patients who were suspected as CAD were included in this study. RT-3DE was performed first. After the analysis, we got the data: ejection fraction (EF), 16 segments systolic dyssynchronic index (SDI 16). All subjects should take the coronary angiography.According to coronary angiography results, the patients with the vascular stenosis rate ≥50% were defined as the CAD group, and the patients with the vascular stenosis rate <50% were defined as the coronary atherosclerosis group, the patients with the completely normal angiographic results were included in the control group according to the results of angiography. The parametric differences among the groups were compared. Results There was no significant difference in LVEF among the three groups. SDI 16 had no significant difference between the control group and the coronary atherosclerosis group (t=-1.03, P>0.05). However, SDI 16 had significant difference between the control group[(3.72±2.68)%]and the CAD group[(7.14±3.10)%], the same between coronary atherosclerosis group[(5.12±3.46)%] and the CAD group[(7.14±3.10)%](t=-3.71, -2.34, all P<0.05). ROC curve analysis revealed that a cut-off value for SDI of 5.49%, yielded a sensitivity of 81.8%, with a specificity of 73.1% to predict coronary atherosclerosis to CAD(AUC=0.743). Conclusion SDI 16 >5.49% has a higher value in evaluating systolic dyssynchrony in patients with CAD with RT-3D of Siemens Acuson SC2000 ultrasonic diagnostic instrument. Key words: Coronary artery disease; Echocardiography, stress