Preliminary application of yellow fluorescein -guided technique in the operation of intracranial malignant tumors

Abstract

Objective To investigate the role of yellow fluorescein-guided technique in the operation of intracranial malignant tumors. Methods From March 2014 to July 2014, the clinical data of 21 patients with intracranial malignant tumor diagnosed before procedure at the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University were analyzed retrospectively. The tumors of 21 patients were resected using the PENTERO 900 fluorescence microscope equipped with YELLOW 560 nm filter during procedure. According to intraoperative fluorescence staining of the tumors, the tumor borders were identified, and the tumors were removed with ultrasound technique. Results No contrast agent-related adverse events occurred in 21 patients during procedure. Nineteen patients had fluorescent development during procedure, no yellow fluorescent staining or weak fluorescent staining of tumors in 2 cases was observed. Postoperative pathological diagnosis: 13 patients had glioblastoma, 4 had anaplastic astrocytoma, 2 had anaplastic oligodendroglioma, 1 had glial sarcoma and 1 had metastases complicated with anaplastic astrocytoma. Conclusion For intracranial malignant tumors, yellow fluorescence-guided technique is contribute to identifying tumor borders and improves the safety and effectiveness of the operation. Key words: Brain neoplasms; Fluorescein; Microsurgery; Assistive technology