Abstract
Objectives: For preimplantation genetic diagnosis (PGD) where only one or two cells (no more than 25% of the blastomeres) are available, fluorescent in situ hybridization (FISH) can be used, for sexing embryos at risk of passing on X-linked disorders for which there is, as yet, no specific molecular diagnosis. In addition, FISH is useful for couples who are subfertile owing to chromosomal disorders, recurrent miscarriage or maternal age. Since first report the use of FISH for PGD several improvements to the technique have been made. However, cell embryos can be lost during the PGD procedure for several factors. The purpose of this study was to assess the PGD results and probable failure causes.
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