Pregnancy-induced hypertension is associated with maternal history and a risk of cardiovascular disease in later life: A Japanese cross-sectional study

Abstract

ObjectiveTo clarify the associations between pregnancy-induced hypertension (PIH) with heritability of PIH from mother to daughter and the risk of cardiovascular disease in later life in Japanese women. Study designThe Japan Nurses’ Health Study (JNHS) is a cohort study of Japanese women's health. Data from the JNHS baseline survey between 2001 and 2007 were used to conduct a cross-sectional analysis. Of the 49,927 respondents in the baseline survey, 10,456 parous women who were ≥45 years old at baseline were included in the analysis. Main outcome measuresThe age-adjusted odds ratio (OR) of PIH in women whose mother had a history of PIH, and the age-adjusted OR of PIH in participants for hypertension, hypercholesterolemia and diabetes mellitus (DM). ResultsThe age-adjusted OR of PIH was 2.72 (95% confidence interval [CI]: 2.14–3.46) in women whose mother had a history of PIH compared with those whose mother did not have PIH. PIH was a risk factor for hypertension (age adjusted OR: 2.85, 95% CI: 2.45–3.11), hypercholesterolemia (age-adjusted OR: 1.49, 95% CI: 1.29–1.72) and DM (age-adjusted OR: 1.53, 95% CI: 1.11–2.11), as determined by logistic regression analysis. ConclusionsIn Japanese women, the risk of PIH is approximately 2.7-fold greater in those whose mothers also had PIH compared with those whose mothers did not. PIH is a risk factor for hypertension, hypercholesterolemia, and diabetes mellitus in later life.