Abstract
Introduction Sickle cell disease (SCD) is one of the most common genetic diseases in the world. It combines, in its homozygous form, chronic hemolytic anemia, vasoocclusive complications, and susceptibility to infections. It is well known that the combination of pregnancy and sickle cell disease promotes the occurrence of complications that are sometimes fatal for the mother and/or the fetus. Objective The objective of the current study was to compare pregnancy outcomes among women with SCD with those of women without the diagnosis of SCD. Materials and methods. It was a case-control study carried out in four maternity hospitals in Brazzaville in 2 years (July 2017–June 2019). It concerned 65 parturients with SS homozygous SCD. The mode of childbirth and maternal and perinatal morbidity and mortality were compared with those of 130 non-sickle cell pregnant women. Results The average age was 27 years for SCD women and 31 years for non-SCD women. The average gestational age at delivery was 35 weeks for SCD women and 38 weeks for non-SCD women. From the logistic regression analysis using the comparison group as the reference group, there was excessive risk in SCD compared to non-SCD of infection (29.3% vs. 4.6%, OR = 21.7, 95% CI [7.6–62.7]; p=0.001), cesarean (63% vs. 35.4%, OR = 3.1, 95% CI [1.6–5.7]; p=0.001), prematurity (75.4% vs. 30.8%, OR = 8, 95% CI [3.0–23.2]; p=0.001), low birth weight (52.3% vs. 16.1%, OR = 4.7, 95% CI [2.4–9.4]; p=0.001), neonatal requiring admission to the intensive care unit (40.3% vs. 17.5%, OR = 3.2, 95% CI [1.6–6.3]; p=0.01), and neonatal death (21.5% vs. 4.8%, OR = 4.3, 95% CI [1.5–12.2]; p=0.01). Conclusion The risk of pregnancy in patients with homozygous sickle cell anemia remains high, on both the maternal and fetal sides.
Highlights
Sickle cell disease (SCD) is one of the most common genetic diseases in the world
It is well known that the combination of pregnancy and sickle cell disease promotes the occurrence of complications that are sometimes fatal for the mother and/or the fetus
Sixty-five of them were included in the study and their data had been compared to that of 130 non-SCD parturients. e average age was 27 years (17 years–42 years) for SCD women and 31 years (16 years–41 years) for non-SCD women. e average gestational age at delivery was 35 weeks (34 weeks–37 weeks) for SCD women and 38 weeks (37 weeks–39 weeks) for non-SCD women
Summary
E improvement in survival secondary to therapeutic progress allows more and more pregnancies in sickle cell women [3] These pregnancies are at very high maternal and fetal risk [4]. 2. Materials and Methods is was a case-control study carried out in the obstetrics and gynecology departments of the 4 main hospitals in the city of Brazzaville: University Hospital of Brazzaville (UHB), Specialized Mother and Child Hospital Blanche Gomez (SMCH), Talangaı Hospital (TH), and Makelekele Hospital (MH). Materials and Methods is was a case-control study carried out in the obstetrics and gynecology departments of the 4 main hospitals in the city of Brazzaville: University Hospital of Brazzaville (UHB), Specialized Mother and Child Hospital Blanche Gomez (SMCH), Talangaı Hospital (TH), and Makelekele Hospital (MH) It was conducted over a period of 24 months (July 01, 2017–June 30, 2019). Logistic regression was applied in order to identify the associated factors having a great power and to eliminate those of confusion
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
