Abstract
The influence of PGF 2α on pregnancy and fetal outcome was investigated in the hamster. Following subcutaneous treatment with 50, 100, 200, 400, and 800 μg PGF 2α prenatal loss was significantly increased only at the highest dose level. The offspring of the treated animals were all alive and normal. Fetal weight was not affected. However, following intravenous injection of 100 and 200 μg PGF 2α there was a significant reduction in fetal weight, and at the 400 μg dose level an increase in fetal resorptions. All fetuses recovered were alive and normal. These results indicate that PGF 2α is not teratogenic in hamsters despite the apparent greater sensitivity of the hamster embryo to prostaglandin.
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