Abstract
Preferences for NaCl, sucrose, HCl and quinine were examined in rats fed a diet containing D-penicillamine (D-pen), and compared with those of normal control rats. Preferences for NaCl and sucrose were reduced by administration of D-pen, and returned to normal upon cessation of D-pen administration. Change in preferences for NaCl and sucrose depended on the amount as well as the duration of D-pen administration. Preferences for HCl and quinine were unaffected by D-pen. No significant difference in the threshold and magnitude of the chorda tympani nerve responses to the taste stimuli was found between D-pen treated and normal rats. Concentrations of electrolytes in serum and saliva were scarcely changed by D-pen administration, but the amount of serum copper was markedly reduced. Effect of D-pen on sensitivity of taste receptors and role of copper ions in regulating fluid intake are discussed.
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