NaCl preference increases during pregnancy and lactation: assessment using brief access tests

Abstract

Pregnancy and lactation are characterized by increases in NaCl intake, as determined by long-term consumption tests, which cannot examine the relative contribution of taste and postingestive factors to this phenomenon. Consequently, in this study, changes in NaCl preference during pregnancy and lactation were studied in nulliparous Long–Evans rats using a brief access test (lickometer). In Experiment 1, rats were maintained on a Na +-adequate diet (0.03% Na +), habituated to lickometer testing, and subsequently assessed during pregnancy and lactation with three 30-s exposures to each of seven taste solutions: 0.075 M sucrose (base), 0.089 M NaCl in base, 0.158 M NaCl in base, 0.281 M NaCl in base, 0.5 M NaCl in base, 0.158 M NaCl and 0.281 M NaCl. Results indicated higher lick rates to the 0.5 M NaCl in base, 0.158 M NaCl and 0.281 M NaCl solutions during late pregnancy and late lactation (Day 13 and beyond). In Experiment 2, a comparison of two diets differing in sodium content (0.03% vs. 0.3% Na +) determined that these changes in NaCl preference during pregnancy and lactation were unrelated to dietary sodium. Thus, the apparent increase in NaCl preference during pregnancy and lactation, independent of dietary sodium, suggests that this change in preference is not in response to physiological sodium need.