Abstract
This chapter provides an overview of Advances in Organ Biology , Volume 6. Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alterations, including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for prevention of myocardial injury.
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