Preface

Abstract

DNA sequence specificity plays a critical role in a number of biological processes, and influences a diverse range of molecular recognition phenomena, including protein–DNA, oligomer–DNA, and ligand–DNA interactions. This chapter provides an up-to-date view of both established and emergent trends in research involving DNA-interactive agents with an emphasis on sequence specificity. The series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro ) for the study of these critical interactions. For the understanding of the genome and proteome expands, general developments in the field of DNA, sequence-specific interactions plays an increasingly important role. The chapter discusses small molecules with highly specific groove binding, molecules with affinity for unique DNA microenvironments, oligonucleotides capable of stabilizing unique DNA architectures, macromolecules that form unique ternary complexes, and molecules, which influence the recruitment and assembly of transcription factors.