Abstract
Abstract. The study of prednisone safety for treatment of TB mixed with HIV-infection has been conducted. Two groups of patients were compared. The first group was consisted of 88 patients who were treated by prednisone and standard tuberculosis therapy, the second group of patients presented by 45 patients received only tuberculosis medicines. It was demonstrated that in case of prednisone using (1st group) the number of CD4 limphocytes increased, intoxication symptoms disappeared fast and recovery process accelerated. Increasing of cases with unfavorable course of TB and HIV-infection in patients of first group was not registered in compare with the second group. Thus, using of prednisone therapy to treat TB mixed with HIV-infection was safe, not lead to unfavorable course of TB or HIV-infection. Such kind of treatment especially important for patients with exudative reactions.
Highlights
The study of prednisone safety for treatment of TB mixed with HIV-infection has been conducted
The first group was consisted of 88 patients who were treated by prednisone and standard tuberculosis therapy, the second group of patients presented by 45 patients received only tuberculosis medicines
Increasing of cases with unfavorable course of TB and HIV-infection in patients of first group was not registered in compare with the second group
Summary
БЕЗОПАСНОСТЬ ТЕРАПИИ ПРЕДНИЗОЛОНОМ В ЛЕЧЕНИИ БОЛЬНЫХ ТУБЕРКУЛЕЗОМ И ВИЧ-ИНФЕКЦИЕЙ. Проведено изучение безопасности применения преднизолона у больных ВИЧ-инфекцией и туберкулезом. Показания к назначению этого препарата больным туберкулезом разработаны еще в середине ХХ века — это формы туберкулеза с выраженной экссудативной реакцией: острый милиарный туберкулез легких, туберкулезные серозиты [12]. 4 специализированным отделением для лечения туберкулеза у больных ВИЧ-инфекцией ФГБУ Санкт-Петербургский НИИ фтизиопульмонологии МЗ РФ, Санкт-Петербург, Россия; Мукомолов С.Л., д.м.н., профессор, зав. Инфекция и иммунитет тельного процесса на фоне применения преднизолона и отсутствие отрицательного влияния на течение ВИЧ-инфекции [7, 9, 14, 16, 17]. Целью данной работы явилось определение влияния терапии преднизолоном на течение туберкулеза и ВИЧ-инфекции, а также уровень CD4 лимфоцитов в крови
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