Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis

Ariana De Castro Tavares Da Silva,Francisco Sávio De Moura Martins,Atticcus Tanikawa,Antônio Fernando De Melo Vaz,Talles Monte De Almeida,José Rômulo Soares Dos Santos,Rosangela Maria Nunes Da Silva,Brunna Muniz Rodrigues Falcão,Almir Pereira De Souza,Vanessa Lira De Santana

doi:10.1590/0103-8478cr20200335

Ariana De Castro Tavares Da Silva, Francisco Sávio De Moura Martins + Show 8 more

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https://doi.org/10.1590/0103-8478cr20200335

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ABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline.

Highlights

Canine monocytic ehrlichiosis (CME) is a severe infectious disease caused by bacteria of the genus Ehrlichia
Ten dogs were selected for the study, between males and females, of different ages and weights, clinically diagnosed with CME from the outpatient care of the Small Animal Medical Clinic (CMPA), at the Professor Ivon Macêdo Tabosa University Veterinary Hospital (HVUIMT), from the Federal University of Campina Grande (UFCG), Patos, attended from October 2014 to January 2016
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis

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Introduction

Canine monocytic ehrlichiosis (CME) is a severe infectious disease caused by bacteria of the genus Ehrlichia. In Brazil, the disease is distributed in all regions of the country. This is mainly due to its vector, the tick Rhipicephalus sanguineus. It is one of the most important diseases in dogs, represented by Approved 06.18.20 Returned CR-2020-0335.R1 by the author 10.17.2C0 iência. In the city of Patos/ PB, an occurrence ranging from 69.4% (TANIKAWA et al, 2013) to 72.5% (AZEVEDO et al, 2011) was observed. The relevance of this disease in the routine of the medical clinic is due to the high casuistry, the high morbidity and mortality caused by the infection and the lack of a vaccine

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