Abstract
Introduction: Right ventricular infarction (RVI) significantly increases the risk of in-hospital mortality in patients with acute inferior infarction of the left ventricle (AIILV). The present study evaluated pre-procedural and intra-procedural predictors of in-hospital mortality in patients with AIILV, accompanied by right RVI, when treated with primary percutaneous coronary intervention (PCI). Methods: 237 patients with acute inferior infarction of the left ventricle accompanied with RVI and treated with PCI were admitted to the Coronary Care Unit at Clinical Centre of Serbia, from 2007 until 2009. In-hospital mortality was 4.2%. Results: Using a multivariate logistic regression model, two independent risk-factors for in-hospital mortality were identified: cardiogenic shock caused by right ventricular insufficiency (54.5% vs. 4.5% without cardiogenic shock, p=0.002) and post-procedural TIMI flow 1 (p = 0.019) and previous PCI (p=0.021). Conclusions and clinical implications: Cardiogenic shock and post-procedural TIMI flow <3 in the infarcted artery are independent predictors of in-hospital mortality. In patients without cardiogenic shock, the risk for in-hospital mortality correlates with the degree of left ventricular insufficiency and previous PCI.
Highlights
Right ventricular infarction (RVI) significantly increases the risk of in-hospital mortality in patients with acute inferior infarction of the left ventricle (AIILV)
RVI significantly increases the risk of in-hospital mortality in patients with AIILV, limited information is available about predictors of in-hospital mortality in these patients
The aim of the present study was to determine pre-procedural and intra-procedural predictors of in-hospital mortality in patients with AIILV, accompanied by RVI, who were treated with percutaneous coronary intervention
Summary
Right ventricular infarction (RVI) significantly increases the risk of in-hospital mortality in patients with acute inferior infarction of the left ventricle (AIILV). The present study evaluated pre-procedural and intra-procedural predictors of in-hospital mortality in patients with AIILV, accompanied by right RVI, when treated with primary percutaneous coronary intervention (PCI). It is estimated that 30% of all acute inferior myocardial infarctions of the left ventricle (AIILV) is associated with right ventricular infarction (RVI) [1,2]. The occurrence of the RVI during AIILV is associated with high in-hospital mortality and morbidity [6,7]. The treatment of these patients involves primarily early reperfusion. Reperfusion, either by thrombolysis or percutaneous coronary intervention (PCI) enhances the recovery of RV function and improves clinical outcome and survival [8,9,10]
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