Abstract
Objective: Warfarin is amongst the most frequently used oral anticoagulant, that is often prescribed to control and prevent various thromboembolic diseases like venous thromboembolism, stroke, atrial fibrillation, and valvular heart disease. This study aimed to determine various predictors and their impact on overall HRQoL among warfarin patients.
 Methods: A cross-sectional study using WHOQOL-BREF research tool was conducted among warfarin patients. Data was collected by convenience sampling method. Descriptive, comparative, and inferential statistics were used by Statistical Package for the Social Sciences (SPSS) ver. 24 to determine the predictors of HRQoL among warfarin patients.
 Results: The majority of the studied warfarin patients were females than males (n=221, 69.3%, and n=98, 30.7% respectively). In univariate analysis, statistically non-significant differences (p >0.05) were observed in gender, age, marital status and work. In multivariate analysis, significant differences (p <0.05) were observed in education, warfarin usage, and warfarin therapy duration.
 Conclusion: These results indicated that education, warfarin usage, and warfarin therapy duration were the pure predictors of HRQoL among the studied cohort of the warfarin patients.
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