Abstract
The purpose . Тo study set of the risk factors (RF) which are most significantly connected with risk of coronary atherosclerosis at men with the metabolic syndrome (MS). Material and methods . The research included 82 men from MS by criteria of ВНОК, 2009, at the age of 39 - 73 years (56,42±7,3 years). Group 1 (n=40), patients with MS and a coronary heart disease: angina of pectoralis of IIIII f.cl. and a coronary atherosclerosis according to a coronaroangiography, group 2 (n=42), patients about the MS which don’t have a coronary heart disease: angina of pectoralis and symptoms of coronary atherosclerosis. In groups of comparison the analysis of the main and additional metabolic RF and by means of a method of logistic regression search of the most adverse set of RF bound to a coronary atherosclerosis at patients with MS was carried out. Results . At patients of group 1 (n=40) higher rates of insulin (р<0,001), HOMA-IR index (р<0,001), Apo B (р<0,05), LPa (р<0,05), IL-6 (р<0,05), ФНО-α (р<0,05), CRP (р<0,05) and lower indicators of ApoA1 (р<0,05), apelin (р<0,001), than in group 2 (n=42) were defined. The predictors which are the most significantly connected with coronary atherosclerosis at patients with in steel MS: apelin, ApoB, insulin, IL-6, CRP and waist circumference. Conclusion . The received set of predictors allows to choose more perspective and schemes of prophylaxis of cardiovascular complications at patients with MS are rational. The obtained data, are also valuable material for carrying out further scientific research with studying of a role of neurohormonal and pro-inflammatory activity of visceral adipose tissue in risk of development of a coronary heart disease in patients with MS.
Highlights
Ключевые словпао:ибсикоднеагирбадоилреуеемныееблпаолгоипмрериыя,тсноосйудсиосвтыойкугрпанфотс, триосФтоРв, ысвеяфзаакнтноырых.с коронарным атеросклерозом у пациентов с метаболическому синдрому (МС)
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The predictors which are the most significantly connected with coronary atherosclerosis at patients with in steel MS: apelin, ApoB, insulin, IL-6, CRP and waist circumference
Summary
The received set of predictors allows to choose more perspective and schemes of prophylaxis of cardiovascular complications at patients with MS are rational.
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