PREDICTORS OF CLINICAL PHENOTYPES FORMATION IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION OF NORTHERN BUKOVINA RESIDENTS

Abstract

The aim of research–to analyze predictors of clinical phenotypes in patients with essentialarterial hypertension (EAH), taking into account patients’ complaints, cardiovascularrisks (CVR) and determine their relationship with the progression of EAH.Methods. The case-control study involved 100 patients with EAH stage II, 1-3 degreesof blood pressure (BP) elevation, high and very high CVR, 21% (21) men, 79% (79)women. The mean age of patients was 56.86 ± 5.52 y.o. The control group consistedof 60 practically healthy individuals, comparable in age and gender.Results. Cardiac phenotype in patients with EAH is manifested by probably morefrequent complaints of heart pain and breath shortness 36.92% (χ2=14.12; p<0.001) and17.23% (p=0.016) correspondingly at BP>160/90 mm Hg. Cerebrovascular phenotypeis associated by more frequent complaints of headache – 39.98% (χ2=15.57; p<0.001).The edematous phenotype is associated with more frequent complaints of peripheraledema – by 22.5% (χ2=9.35; p=0.002). For BP ≥160/90 mm Hg patients more oftencomplain of neuropathic and/or vasomotor disorders (paresthesias, muscle weakness/spasm, tension or agitation, anxiety, palpitations, hot fl ashes, BP changes, etc.) – 23.55%(χ2=4,57; p=0.032), as well as visual impairment – 30.65% (χ2=10.34; p=0.001).Conclusions. Predictors of more severe EAH in the inhabitants of Northern Bukovinaare: cardiac pain, shortness of breath, headache, peripheral edema, the appearanceof neuropathic- vasomotor changes and visual impairment associated with EAH. The riskof severe EAH increases almost threefold by SCORE> 5.0.