Abstract
Aim. To study the relationship between central arterial pressure (BP) and cystatin C in patients with arterial hypertension and comorbid pathology, depending on gender differences.
 Materials and methods. The study involved 162 patients aged 39 to 82 years, suffering from hypertension and comorbid pathology. The average age of the surveyed was 58.610.3 years. The following nosological forms were revealed: coronary heart disease 40.7% of the examined, overweight 33.9%, 1st degree obesity 30.8%, type 2 diabetes mellitus 29.0%, chronic obstructive disease lungs 16.6%, cerebrovascular diseases 13.5%. All participants underwent general clinical examinations. The concentration of the lipid spectrum was investigated: the levels of total cholesterol, triglycerides, cholesterol high density lipoproteins (HDL cholesterol) and low density lipoprotein cholesterol (LDL cholesterol) and plasma cystatin C. Glomerular filtration rate (GFR) was calculated according to F. Hoek's formula (80.35/cystatin C 4.32=GFR). Study of central aortic pressure (CAP), mm Hg Art., was carried out using the device "AngioScan". Echocardiography was performed on a "Vivid q" apparatus (USA, 2014) according to the generally accepted technique. All examined patients were divided into 2 subgroups. The 1st subgroup includes women, the 2nd men.
 Results. In patients with hypertension and comorbid pathology, the most common abnormalities were an increased level of LDL cholesterol (58%), a decreased level of HDL cholesterol (51.8%), hypercholesterolemia (54.3%), hypertriglyceridemia (43.8%) and tachycardia (40.7%). In 51.8% of the surveyed, and more among males, the achievement of the target blood pressure level was detected. In women, the indicators of average age, body mass index, the content of total cholesterol, LDL cholesterol and HDL cholesterol were significantly higher. In male patients, the indicators of the diameter of the aortic outflow tract, end systolic and diastolic dimensions of the left ventricle (LV) significantly exceeded those of women, and the ejection fraction of the LV was significantly lower. The prevalence of LV hypertrophy (LVH) was 37% in the total sample, and it was higher in women than in men (45.9 and 26.6%, respectively, p=0.012). At the same time, the frequencies of concentric and eccentric types of LVH in both subgroups were similar. The incidence of LV concentric remodeling in women and men was 5.7 and 13.3%, respectively (p=0.001). In both subgroups, a negative correlation was found between the LV myocardial mass index and the calculated GFR. A positive correlation was noted between the levels of systolic blood pressure and CAP, the concentrations of cystatin C and plasma triglycerides.
 Conclusion. In hypertension, the structure of comorbid pathology is dominated by coronary heart disease, obesity and type 2 diabetes mellitus, when hyper- and dyslipidemia were often detected. The incidence of LVH in the general group of subjects was 37.0%, and in women this indicator was higher. In the subgroup of men, cases of LV concentric remodeling were significantly more frequent. An increase in the level of CAP and systolic blood pressure, as well as the concentration of cystatin C, was associated with an increase in the LV myocardial mass index, especially in the subgroup of women.
Highlights
The prevalence of left ventricle (LV) hypertrophy (LVH) was 37% in the total sample, and it was higher in women than in men (45.9 and 26.6%, respectively, p=0.012)
A negative correlation was found between the LV myocardial mass index and the calculated Glomerular filtration rate (GFR)
A positive correlation was noted between the levels of systolic blood pressure and central aortic pressure (CAP), the concentrations of cystatin C and plasma triglycerides
Summary
Изучить взаимосвязь центрального артериального давления (АД) и цистатина С у больных артериальной гипертензией (АГ) и коморбидной патологией в зависимости от гендерных различий. У больных АГ и коморбидной патологией наиболее распространенными отклонениями оказались повышенный уровень ХС ЛПНП (58%), пониженный уровень ХС ЛПВП (51,8%), гиперхолестеринемия (54,3%), гипертриглицеридемия (43,8%) и тахикардия (40,7%). У женщин показатели среднего возраста, индекса массы тела, содержания общего ХС, ХС ЛПНП и ХС ЛПВП были значимо выше. Частота встречаемости концентрического ремоделирования ЛЖ у женщин и мужчин составляла 5,7 и 13,3% соответственно (p=0,001). Частота встречаемости ГЛЖ в общей группе обследуемых составляла 37,0%, причем у женщин этот показатель был выше. Рост уровня ЦАД и систолического АД, а также концентрации цистатина С ассоциировался с увеличением индекса массы миокарда ЛЖ, особенно в подгруппе женщин. Неврологии, психиатрии и медицинской генетики медицинского фак-та ОшГУ, член правления Общества специалистов по хронической болезни почек Киргизии.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.