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Abstract
Clinical findings about the adverse effects of the use of antiretroviral drugs in the oral cavity of people with HIV / AIDS began to be found. A case regarding the side effects of the use of antiretroviral drugs is the discovery of oral cavity lesions in the form of whitish plaque on the lips and right buccal mucosa that has occurred more than one month accompanied by complaints of taste disorders, xerostomia, and a burning feeling in the mucosa of patients using Nevirapine, Zidovudine and Lamivudine. This study was to analyze the relationship of anti-retroviral treatment in HIV AIDS sufferers to caries predictors, and caries severity, and analyze the relationship between the duration of antiretroviral treatment to caries predictors and caries severity. This study used an observational method with cross sectional or cross sectional design by conducting direct observations, on 100 samples of HIV / AIDS sufferers using anti-retroviral drugs at the Yayasan Peduli Kelompok Dukungan Sebaya (YPKDS) Makassar held in October 2019. Data were analyzed with chi square test.
Highlights
AIDS stands for Acquired Immune Deficiency Syndrome, which is a decrease in the body's resistance to various diseases due to infection with the HIV virus (HumanImmunodeficiency Virus)
Patients with caries predictors (p = 0.357) and caries severity (p = 0.005), while analysis of the duration of antiretroviral treatment is less than 5 years and more than 5 years there is no relationship with caries predictors (p = 0.730) and caries severity (p = 0.428)
A case regarding the side effects of the use of antiretroviral drugs was reported by Moura, et al, namely the discovery of oral cavity lesions in the form of whitish plaque on the lips and right buccal mucosa that has occurred more than one month accompanied by complaints of taste disorders, xerostomia, and a burning feeling in the patient's mucosa which uses Nevirapine, Zidovudine, and Another case was reported by Liza Meutia Sari et.all, who found Stevens-Johnson Syndrome (SSJ) in a patient using combination antiretroviral drug therapy consisting of Duvival (Zidovudine 300 mg and Lamivudine 150 mg) and Neviral (Nevirapine 100 mg) twice a day [4]
Summary
AIDS stands for Acquired Immune Deficiency Syndrome, which is a decrease in the body's resistance to various diseases due to infection with the HIV virus A case regarding the side effects of the use of antiretroviral drugs was reported by Moura, et al, namely the discovery of oral cavity lesions in the form of whitish plaque on the lips and right buccal mucosa that has occurred more than one month accompanied by complaints of taste disorders, xerostomia, and a burning feeling in the patient's mucosa which uses Nevirapine, Zidovudine, and Lamivudine [3] Another case was reported by Liza Meutia Sari et.all, who found Stevens-Johnson Syndrome (SSJ) in a patient using combination antiretroviral drug therapy consisting of Duvival (Zidovudine 300 mg and Lamivudine 150 mg) and Neviral (Nevirapine 100 mg) twice a day [4]. There are 3 main factors that play a role, namely the host factor, agent (microorganism), substrate (diet) and plus the time factor, which is described as three overlapping circles for caries, the condition of each of these factors must be vulnerable host, cariogenic microorganisms, suitable substrate and long time
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