Predictive value of serum lactate combined with PIRO score in prognosis of septic patients

Abstract

Objective To investigate the predictive value of serum lactate combined with PIRO (Predisposition, Infection, Response and Organ dysfunction) score in the development of multiple organs dysfunction syndrome (MODS) in septic patients and to study procalcitonin (PCT), in order to provide guidelines for clinical care. Methods From April 2015 to July 2016, a total of 752 sepsis patients were enrolled and divided into MODS group (n=488) and non-MODS group (n=264) according to the criteria of MODS. At 28 d after admission, these patients were divided into survival group (n=477) and death group (n=275). PCT and lactate levels in serum were measured, and PIRO score of these patients was calculated. Then the differences in levels of PCT and lactate in serum were compared among patients at different PIRO score categories. ROC was constructed to observe the clinical values of the biomarkers, PIRO score and lactate combined with PIRO score in predicting prognosis. Result PCT, lactate levels in serum and PIRO score were significantly higher in MODS group and death group, showing significant positive correlation. The areas under ROC curves (AUCs) of serum lactate combined with PIRO score for predicting MODS were 0.906, which was significantly higher than that of serum PCT (0.716), serum lactate (0.851) and PIRO score (0.840) alone (all P<0.05). Serum PCT, serum lactate and PIRO score were the independent predictors of MODS. Conclusions Serum lactate in combination with PIRO score was a valuable indicator in predicting development of MODS in septic patients. Key words: Sepsis; PCT; Lactate; PIRO; MODS