Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients.

Hai Lin,Lifen Huang,Zhouling Li,Cheng Meng,Manlian Zhu

doi:10.12669/pjms.38.3.5204

Hai Lin, Lifen Huang + Show 3 more

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https://doi.org/10.12669/pjms.38.3.5204

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Abstract

Objectives:To investigate the potential predictive value of serum adiponectin (APN) and hemoglobin (Hb) levels for the occurrence of vascular cognitive impairment in ischemic stroke patients.Methods:Eighty ischemic stroke patients, admitted to our hospital between June 2019 and November 2020, were retrospectively divided into no cognitive impairment (NCI) group (n=43) and cognitive impairment (CI) group (n=37) based on Montreal Cognitive Assessment (MoCA) scale scoring at three months follow-up. ELISA was used to assess serum Hb and APN levels and receiver operating characteristic (ROC) curves were created to evaluate correlation.Results:Serum APN and Hb levels were lower in the vascular cognitive impairment group compared to non-impaired counterparts. Pearson correlation analysis showed that both APN and Hb levels were positively correlated with MoCA scores. Area under curve analysis indicated predictive value for serum APN and Hb for predicting cognitive impairment in ischemic stroke patients.Conclusion:Serum APN and Hb levels in ischemic stroke patients have value for predicting vascular cognitive impairment and may be suitable for helping dictate treatment planning.

Highlights

Ischemic stroke incidence is high in the Chinese elderly population, as is mortality and disability rate
Pearson correlation analysis showed that serum APN and Hb levels were positively correlated with MOCA score (r = 0.447 and 0.452, respectively, P < 0.01)
Univariate analysis showed that serum VPN, Hb, Hcy, high-sensitivity C-reactive protein (hs CRP), and systolic blood pressures (SBP) were associated with vascular cognitive impairment in patients with ischemic stroke (P < 0.05)

Summary

Introduction

Ischemic stroke incidence is high in the Chinese elderly population, as is mortality and disability rate. Pak J Med Sci March - April 2022 Vol 38 No 3 www.pjms.org.pk 705 both groups six months after the index event using the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD Vascular dementia pathogenesis involves oxidative stress responses, which can be detected by measuring serum hemoglobin (Hb) levels.[5] adiponectin (APN) has been recently found to improve vascular dementia in patients with atherosclerosis, glucose metabolism disorder, and hypertension.[6] the value of serum APN and Hb levels for predicting vascular cognitive impairment in ischemic stroke patients has not been investigated. This study examined the serum APN and Hb levels of 80 ischemic stroke patients and used this data to examine the relationship between these parameters and vascular cognitive impairment probability

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