Predictive value of preprocedural albuminuria for contrast-induced nephropathy non-recovery in patients undergoing percutaneous coronary intervention

Abstract

Abstract Background The degree of renal recovery from contrast induced nephropathy (CIN) may affect long-term outcomes. Albuminuria had been generally considered to be an independent risk factor of CIN. However, the predictive value of albuminuria for CIN non-recovery in patients undergoing percutaneous coronary intervention (PCI) remains unknown. Purpose To evaluate the association of preprocedual albuminuria and CIN non-recovery after PCI. Methods From January 2012 to December 2018, 550 consecutive patients developing CIN after PCI and reassessing kidney function among 1 to 12 months were enrolled. CIN non-recovery was defined as a relative decrease of serum creatinine ≥25% or 0.5 mg/dl over baseline at 1 to 12 months in patients who developed CIN. Patients were stratified into three groups according to urinary albumin: negative group (urine dipstick negative), trace group (urine dipstick trace) and positive group (urine dipstick ≥1+). Results Overall, 88 (16%)patients had trace urinary albumin, 74 (13.5%) patients had positive urinary albumin and 40 (7.3%) patients developed CIN non-recovery. Patients with positive urinary albumin had significantly higher incidence of CIN non-recovery [negative (3.4%), trace (11.4%) and positive (23.0%), respectively; P<0.0001]. Multivariate analysis showed that trace and positive urinary albumin were associated with an increased risk of CIN non-recovery (trace vs. negative: OR: 2.879, P=0.022; positive vs negative: OR: 2.991, P=0.021). Conclusion Preprocedural albuminuria was associated CIN non-recovery in patients undergoing PCI. Incidence of CIN non-recovery Funding Acknowledgement Type of funding source: None