Abstract
This study was aimed at exploring the predictive value of first-trimester glycosylated hemoglobin (HbA1c) levels in the diagnosis of gestational diabetes mellitus (GDM). A total of 744 pregnant women registered at the Peking University International Hospital between March 2017 and March 2019 were included in this study. Data on personal characteristics and biochemical indicators of the pregnant women were collected during the first trimester. The International Association of Diabetes and Pregnancy Study Groups has adopted specific diagnostic criteria as the gold standard for the diagnosis of GDM. Receiver operating characteristic (ROC) curve statistics were used to assess the predictive value of first-trimester HbA1c levels in the diagnosis of GDM. HbA1c levels in the first trimester were significantly higher in the GDM group than in the non-GDM group (5.23% ± 0.29% vs. 5.06 ± 0.28%, P < 0.05). The first-trimester HbA1c level was an independent risk factor for gestational diabetes. The area under the ROC curve (AUC) of HbA1c for GDM was 0.655 (95% confidence interval 0.620-0.689, P < 0.001). The positive likelihood ratio was the highest at HbA1c = 5.9%, sensitivity was 2.78, and specificity was 99.83%. There was no statistical difference in AUC between fasting blood glucose and HbA1c (P = 0.407). First-trimester HbA1c levels can be used to predict GDM. The risk of GDM was significantly increased in pregnant women with first‐trimester HbA1c levels > 5.9%. There was no statistical difference between first-trimester HbA1c and fasting blood glucose levels in predicting GDM.
Highlights
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or first recognition during pregnancy; blood glucose levels in cases of GDM do not reach those indicating obvious diabetes mellitus [1]
144 participants were diagnosed as having GDM, and 600 participants had normal blood glucose levels
The average age of the participants diagnosed with GDM was higher than that of the participants with normal blood glucose levels (32:76 years ± 3:91 years vs. 30:62 years ± 3:64 years, P < 0:05)
Summary
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or first recognition during pregnancy; blood glucose levels in cases of GDM do not reach those indicating obvious diabetes mellitus [1]. Pregnant women with GDM followed up as usual during the COVID-19 pandemic lockdown, their diabetes control was lower, with a higher rate of insulin therapy [3]. Pregnant women with GDM have an increased risk of developing preeclampsia, increased rates of cesarean sections, and an increased risk of macrosomia [4]. Pregnant women with GDM have a significantly increased risk of developing type 2 diabetes mellitus later in life [5, 6]. There is a critical period for fetal organ development in the early stages of pregnancy. The first-trimester HbA1c level is a reliable predictor of complications during pregnancy, including preeclampsia, fetal macrosomia, and large for gestational age birth weight [8]. Fasting blood glucose (FBG) is used as an early screening tool for gestational diabetes.
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